Long weekend travel in late June - San Francisco/Napa, CA or Portland, OR.. or somewhere else?

Hi! I’m looking for some suggestions on where to go for a long weekend in late June from Los Angeles (probably leave on Thursday afternoon, return home Sunday evening). This will be a 40th birthday trip and we’re trying to decide where to go with the limited time I have off from work. We’d be leaving from Los Angeles and open to flying and renting a car, or driving from LA. I’ve never been to any of the places in the subject line (SF, Napa, or Portland), but also if it doesn’t seem feasible, open to other reasonable suggestions. We love the outdoors (beach, mountains, forests, you name it), we also love wine (and breweries), also love just exploring new cities! Would it be too much to try to do SF and Napa together? Or would June be a better time somewhere else like Portland? I just kind of don’t know where to start on planning a trip like this so any suggestions would be welcome. TIA!